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Wednesday, July 15, 2020 | History

3 edition of The use of intertypic recombinants for analysis of gene organization in Herpes Simplex Virus found in the catalog.

The use of intertypic recombinants for analysis of gene organization in Herpes Simplex Virus

Lawrence Sheldon Morse

The use of intertypic recombinants for analysis of gene organization in Herpes Simplex Virus

by Lawrence Sheldon Morse

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  • 18 Currently reading

Published .
Written in English


Edition Notes

Statementby Lawrence Sheldon Morse.
Classifications
LC ClassificationsMicrofilm 81004 (Q)
The Physical Object
FormatMicroform
Paginationix, 148 leaves
Number of Pages148
ID Numbers
Open LibraryOL3093615M
LC Control Number82197043

Herpes simplex virus Research The HSV Genome The HSV-1 genome is a linear, double stranded DNA duplex , base pairs in length, and with a base composition of 67% G + C. The genome circularizes upon infection. Because the genome circularizes, the transcription and genetic map is conveniently shown as a circle. Click image for closer view. This study will examine the structure of the receptor molecule for the herpes simplex virus (HSV) and determine if the receptor's structure is related to susceptibility to infection with the virus. There are two types of herpes virus-HSV-1 and HSV HSV-1 commonly causes .

Session I: Human, Simian and Murine Herpesviruses.- Herpes Simplex Virus Type 1 Thymidine Kinase Gene Activity Controls Virus Latency and Neurovirulance in Mice.- Latency of Herpes Simplex Virus in Tree Shrew; Generation of Intertypic Recombinants of Herpes Simplex Virus in Vivo.- A Review of HSV Latency in Experimental Animals   Herpes simplex virus type 2 (HSV-2) infections are common and increasing with seroprevalence rates now >20% [].Acute infection at the mucosal surface is followed by the establishment of a latent infection in the innervating sensory neurons (reviewed in []).Reactivation can be accompanied by herpetic lesions, but asymptomatic shedding is even more common [3, 4].Cited by:

Progress in development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis Joseph C. Glorioso, David Krisky, Peggy Marconi, Thomas Oligino, Steve C. Ghivizzani, Paul D. Robbins, Martin C. Schmidt, William F. Goins, Christopher EvansCited by: Our analysis has resulted in the identification of protein families or singleton proteins that show clear homology with gene products in the human genome, including new host-virus homologs in human herpesvirus (HHV) 5 (HCMV) and HHV-8 (Kaposi's sarcoma–associated herpesvirus; KSHV).


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The use of intertypic recombinants for analysis of gene organization in Herpes Simplex Virus by Lawrence Sheldon Morse Download PDF EPUB FB2

The use of intertypic recombinants for analysis of gene organization in herpes simplex virus. Morse LS, Pereira L, Roizman B, Schaffer PA.

Analysis of the DNA sequence arrangement and polypeptides specified by 28 HSV-1 x HSV-2 recombinants show the following: (i) Recombinants with heterogeneous L and S components or with heterogenous inverted Cited by: 4.

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of new viruses that produce viral infections in the majority of humans.

Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are common and : incertae sedis. Resistance testing of antivirals to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can be done by phenotypic and genotypic methods.

The determination of a resistant phenotype is based on. Abstract. We have mapped the location in herpes simplex virus (HSV) DNA of (i) three mutations at different loci (syn loci) which alter the social behavior of infected cells from clumping of rounded cells to polykaryocytosis, (ii) a mutation which determines the accumulation of one major glycoprotein [VP(C 2)], and (iii) the sequences encoding four major virus glycoproteins [VP(C 2), VP7 Cited by: The use of intertypic recombinants for analysis of gene organization in herpes simplex virus.

In “Oncogenesis and herpesviruses 3, part 1” (Ed. de The, W. Henle, F. Rapp). (IARC scientific publication). Cited by: 4. Intertypic recombination between herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) was detected using DNA from mixedly infected cells.

Because HSV-1 and HSV-2 share a 50% base sequence homology along the genome but have markedly different DNA restriction enzyme cleavage patterns, recombination events can be detected and quantified by analysis of restriction endonuclease digests Cited by: 2.

The properties of recombinant strains of herpes simplex virus were examined. A total of four recombinants were isolated following the simultaneous infection of African monkey kidney cells with type 1 and type 2 virus.

The resulting variants possessed intermediate characters in both plaque size and cytopathic effect. Further crosses between these stable recombinants indicated that the capacity Cited by: 3. VIROLOGY() Biological Characterization of a Herpes Simplex Virus Intertypic Recombinant Which Is Completely and Specifically Non-Neurovirulent R.

THOMPSON AND J. STEVENS1 Department of Microbiology and Immunology, University of California, Los Angeles, Los Angeles, California Received Ap ; accepted Aug In this study, a pre Cited by: Herpes simplex virus type 1 (HSV-1) is a human pathogen whose lifestyle is based on a long-term dual interaction with the infected host, being able to establish both lytic and latent infections.

The virus genome is a kilobase pair (kbp) double-stranded DNA molecule encoding more than 80 by:   The glycoprotein C (gC) gene of herpes simplex virus type 1 is a true late gene, in that its expression occurs late in infection with a strict requirement for viral DNA replication.

Recently, we reported on gC expression during infection with mutant viruses carrying deletions in Cited by: Recombinant herpesviruses as tools for the study of herpesvirus biology Article Literature Review (PDF Available) in Acta virologica 57(2) April with 97 Reads How we measure 'reads'.

Regulation of herpes simplex virus gene expression Regulation of herpes simplex virus gene expression Weir, Jerry P. Expression of the more than 80 individual genes of herpes simplex virus 1 (HSV-1) takes place in a tightly regulated sequential manner that was first described over 20 years ago.

Investigations since that time have focused on understanding the. Herpes simplex virus 1 p53 Responsive elements Gene expression abstract Analysis of the herpes simplex virus-1 (HSV-1) genome reveals two candidate p53 responsive elements (p53RE), located in proximity to the replication origins oriL and S, referred to as p53RE-L and p53RE-S, respectively.

Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC It can be found in most living cells.

It is present in two forms in mammalian cells, TK1 and TK2. Certain viruses also have genetic information for expression of viral thymidine kinases. Thymidine kinase catalyzes the reaction:BRENDA: BRENDA entry. The Varicellovirus genus is part of the larger alphaherpesvirus subfamily which includes herpes simplex viruses 1 and 2, as well as Marek’s disease virus.

Like other alphaherpesviruses, varicelloviruses typically infect epithelial surfaces, and most appear to be neurotropic, establishing latency in neurons [1,2,3,4,5,6,7,8,9].The first varicellovirus to be clinically described as a unique Cited by: 4.

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two species of the herpes virus family, which cause infections in humans.

An infection by a herpes simplex virus is marked by watery blisters in the skin or mucous membranes of the mouth, lips or genitals. The genomes of HSV-1 and HSV-2 are complex, and contain two unique regions called the.

Herpes simplex virus encephalitis is the leading cause of sporadic, nonepidemic encephalitis in children and adults in the United States.

It is an acute necrotizing infection generally involving the frontal and/or temporal cortex and the limbic system and, beyond the neonatal period, is almost always caused by Herpes simplex virus type on. Herpes Simplex virus is an enveloped, icosahe-dral and double stranded DNA virus large enough to encode roughly 70 transcripts of which only half are required for viral replication 6.

This suggests ample space for recombinant gene insertions and the deliv-ery of multiple genes in one vector. Like other large DNA viruses, HSV has also evolved a.

Herpes simplex virus type 2 (HSV-2) is sexually transmitted, leading to blisters and ulcers in the genito-anal region. After primary infection the virus is present in a latent state in neurons in sensory ganglia. Reactivation and production of new viral particles can cause asymptomatic viral shedding or new lesions.

Establishment of latency, maintenance and reactivation involve silencing of Cited by: 6. Invited Review Gene therapy using herpes simplex virus-based vectors D.S. Latchman Institute of Child Health, University College London, London, UK Summary.

Gene therapy involves the use of specific genes to treat human diseases and is thus critically dependent. In this article we will discuss about Herpes Virus: 1. Introduction to Herpes Virus 2. Classification of Herpes Virus 3.

Herpes Simplex Virus. Introduction to Herpes Virus: Herpes viruses ( nm in diameter) contain icosahedral capsid made of capsomeres, DNA genome and are surrounded by a .HSV1 - UL23 thymidine kinase (TK) gene HSV2 - UL36 large tegument protein gene Herpes Simplex Virus 1 and 2 Techne ® qPCR test tests For general laboratory and research use only Quantification of Herpes Simplex Virus 1 and 2 genomes.

1 Advanced kit handbook HBFile Size: KB.This is the action of the herpes virus. Genital herpes infections are caused by the herpes simplex virus (HSV): a large (nm) DNA virus which consists of approximatelybase pairs of double stranded DNA, encapsulated in a layer made of protein called the capsid.